Search for dissertations about: "Structure-activity correlation"
Showing result 1 - 5 of 12 swedish dissertations containing the words Structure-activity correlation.
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1. In Vitro – In Vivo Correlation of Injectable Lipid Formulations
Abstract : In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. READ MORE
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2. Distribution and Chemical Diversity of Cyclotides from Violaceae : Impact of Structure on Cytotoxic Activity and Membrane Interactions
Abstract : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. READ MORE
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3. Studies on Cytotoxic and Neutrophil Challenging Polypeptides and Cardiac Glycosides of Plant Origin
Abstract : This thesis examines the isolation and characterisation (biological and chemical) of polypeptides from plants. A fractionation protocol was developed and applied on 100 plant materials with the aim of isolating highly purified polypeptide fractions from small amounts of plant materials. READ MORE
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4. Ion channels in drug discovery : focus on biological assays
Abstract : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. READ MORE
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5. Asymmetric transfer hydrogenation of ketones : Catalyst development and mechanistic investigation
Abstract : The development of ligands derived from natural amino acids for asymmetric transfer hydrogenation (ATH) of prochiral ketones is described herein. In the first part, reductions performed in alcoholic media are examined, where it is found that amino acid-derived hydroxamic acids and thioamides, respectively, are simple and versatile ligands that in combination with [RhCp*Cl2]2 efficiently catalyze this particular transformation. READ MORE