Search for dissertations about: "Substance P 1–7"

Showing result 1 - 5 of 8 swedish dissertations containing the words Substance P 1–7.

2. 1. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

   Author : Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

   Abstract : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. READ MORE

4. 2. Renal and parathyroid function in psychiatric patients on lithium treatment

   Author : Hans Bendz; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes insipidus; glomerular filtration rate; hypercalcemia; hyperparathyroidism; lithium; nephrogenic; nephropathy; polyuria;

   Abstract : Aims. To investigate the prevalence and clinical implications of renal and parathyroid morbidity in lithium patients. Patients. Short-term lithium patients (n=162; average 6 treatment years) and long-term patients (n=142; average 19 treatment years) were studied cross-sectionally. READ MORE

5. 3. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site : Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties

   Author : Rebecca Fransson; Anja Sandström; John S Svendsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P 1-7; peptidomimetics; structure-activity relationship; drug-like properties; phenylalanine; imidazole; MAP aryl amides; carbonylation; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. READ MORE

6. 4. Studies on the influence of sensory stimulation (acupuncture) on neuropeptide release in the saliva

   Author : Irena Dawidson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : acupuncture; substance P; neurokinin A; calcitonin gene-related peptide; vasoactive intestinal polypeptide; neuropeptide Y; xerostomia; salivary secretion rates;

   Abstract : The aim of this thesis was to elucidate the mechanisms behind the effect of sensory stimulation (acupuncture) on the salivary flow rates of xerostomic patients. We hypothesised that the sensory stimulation activates the sensory and autonomic nervous systems, leading to an increased release of neuropeptides that influence salivary secretion in co-operation with or/and beside the classical neurotransmitters. READ MORE

7. 5. Microbial biofilms on peritoneal dialysis catheters

   Author : Maria Pihl; Malmö högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peritoneal dialysis; Biofilm;

   Abstract : Då njurarna slutar fungera produceras ingen urin, och avfallsprodukterna stannar kvar i blodet. Detta tillstånd kallas uremi (”urin i blodet”) och leder till döden om det inte behandlas. Det finns två artificiella sätt att rena blodet på, hemodialys och peritonealdialys. READ MORE