Search for dissertations about: "Substrate interaction"

Showing result 21 - 25 of 300 swedish dissertations containing the words Substrate interaction.

  2. 21. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development

    Author : Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; Biochemistry; Biokemi;

    Abstract : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). READ MORE

  4. 22. Structural and dynamical basis of NusA´s role in transcription-coupled DNA repair

    Author : Damasus Okeke; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Resonance assignment; DNA repair; transcription-repair coupling factors; transcription-coupled repair; NusA; DinB; UvrD; autoinhibition; DNA substrate; dynamics.;

    Abstract : DNA repair processes involves a host of repair machineries that are able to recognize and repair the damaged DNA. Nucleotide excision repair (NER) pathway is one of these processes exploited by cells to remove bulky DNA lesions. READ MORE

  5. 23. Gas Metal Arc Melt Pool Modelling : Effect of welding position and electromagnetic force mode

    Author : Pradip Aryal; Isabelle Choquet; Högskolan Väst; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gas metal arc welding; Gravitational force; Substrate orientation; Electromagnetic force modelling; Free surface deformation; Computational Fluid Dynamics; OpenFOAM; Gasmetallbågsvetsning; Gravitation; Svetsläge; Elektromagnetisk kraftmodellering; Smältytans rörelser; Computational Fluid Dynamics; OpenFOAM; Production Technology; Produktionsteknik;

    Abstract : Gas metal arc is a high-efficiency and widely used heat source for metal processing applied predominantly in welding and additive manufacturing. In this study, it was applied to welding. READ MORE

  6. 24. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach : Applications for Drug Discovery and Development

    Author : Aleksejs Kontijevskis; Jarl Wikberg; Jan Komorowski; Robert Glen; Uppsala universitet; []
    Keywords : Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

    Abstract : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. READ MORE

  7. 25. Rational engineering of esterases for improved amidase specificity in amide synthesis and hydrolysis

    Author : Peter Hendil-Forssell; Mats Martinelle; Romas J. Kazlauskas; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Amidase; Biocatalysis; Enzyme; Esterase; Enzyme engineering; Lipase; Substrate specificity; Bioteknologi; Biotechnology;

    Abstract : Biocatalysis is an ever evolving field that uses enzymes or microorganisms for chemical synthesis. By utilizing enzymes that generally have evolved for specific reactions under mild conditions and temperatures, biocatalysis can be a more environmentally friendly option compared to traditional chemistry. READ MORE