Search for dissertations about: "Sunitinib"
Showing result 1 - 5 of 15 swedish dissertations containing the word Sunitinib.
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1. Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy
Abstract : New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. READ MORE
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2. Intratumoral Predictive Markers in Metastatic Renal Cancer Patients
Abstract : There is no established predictive marker for the treatment of metastatic renal cell cancer (mRCC) patients. With a predictive marker, patients unlikely to respond could be selected upfront and offered other therapy options. Thereby, unnecessary toxicity could be avoided and costs would be reduced. READ MORE
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3. Axl RTK and microRNAs in urogenital cancers
Abstract : This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. READ MORE
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4. The role of autophagy in anticancer therapy
Abstract : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. READ MORE
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5. Vascular targeting for enhanced cancer immunotherapy
Abstract : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. READ MORE