Search for dissertations about: "Suprachiasmatic nucleus"

Found 5 swedish dissertations containing the words Suprachiasmatic nucleus.

  1. 1. Circadian rhythm dysfunction in the suprachiasmatic nucleus : Effects of Trypanosoma brucei brucei infection and inflammatory cytokines

    University dissertation from Stockholm : Karolinska Institutet, Department of Neuroscience

    Author : Gabriella B Lundkvist; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

    Abstract : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. READ MORE

  2. 2. Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock

    University dissertation from Stockholm : Karolinska Institutet, Department of Neuroscience

    Author : Mikael Nygård; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Circadian; suprachiasmatic; synaptic; inflammation; cytokine; SOCS; interferon; tumor necrosis factor; neuron; firing;

    Abstract : p>The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker in the mammalian brain and is vital for generating physiological and behavioral circadian rhythms. During aging and inflammatory conditions the circadian system is frequently affected, but relatively little is known about the mechanisms underlying such effects. READ MORE

  3. 3. Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland

    University dissertation from Stockholm : Karolinska Institutet, Dept of Neuroscience

    Author : Arash Hellysaz; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome stressors, and generates outputs that affect the autonomic nervous system, the endocrine system and somatomotor behaviors. READ MORE

  4. 4. Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors

    University dissertation from Stockholm : Karolinska Institutet, Dept of Neuroscience

    Author : Mirko Conti; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric disorders, like depression, later in life. READ MORE

  5. 5. Gene-environment factors in depressive disorders with a focus on circadian genes

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine and Surgery

    Author : Louise Sjöholm; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Depressive disorders have a multifactorial etiology, where both environmental and genetic risk factors contribute. Depression is characterized by a depressed mood and accompanied by e.g. loss of interest and pleasure, disturbed sleep and appetite and difficulties in concentrating. READ MORE