Search for dissertations about: "Surface plasmon resonance SPR"

Showing result 1 - 5 of 68 swedish dissertations containing the words Surface plasmon resonance SPR.

  1. 1. Imaging surface plasmon resonance

    Author : Olof Andersson; Bo Liedberg; Fredrik Björefors; Thomas Ederth; Jiří Homola; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Kemi;

    Abstract : The central theme of this thesis is the use of imaging Surface Plasmon Resonance (iSPR) as a tool in the characterization of surfaces with laterally varying properties. Within the scope of this work, an instrument for iSPR analysis was designed and built. READ MORE

  2. 2. Miniaturized localized surface plasmon resonance biosensors

    Author : Si Chen; Chalmers University of Technology; []
    Keywords : colloidal lithography; Surface plasmon resonance; biosensing; electron beam lithography; single molecule; hyperspectral imaging; photo functionalization;

    Abstract : Abstract Reliable and sensitive biosensors are required for fast and accurate diagnostics. Localized surface plasmon resonances (LSPRs) in noble-metal nanoparticles possess very high refractive index sensitivity close to the metal surface and therefore constitute an attractive biosensing platform. READ MORE

  3. 3. Photochemical Surface Functionalization : Synthesis, Nanochemistry and Glycobiological Studies

    Author : Lingquan Deng; Olof Ramström; Javier Rojo; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Glycobiology; Carbohydrate-protein interactions; Perfluorophenylazide PFPA ; Photochemistry; Carbohydrate surface immobilization; Carbohydrate microarrays; Surface plasmon resonance SPR ; Quartz crystal microbalance QCM ; Atomic force microscopy AFM ; Glyconanomaterials; Concanavalin A Con A ; Cyanovirin-N CV-N ; 1-Glycosyl thiols; Mutarotation; 1-S-glycosylation; Stereocontrol;

    Abstract : This thesis mainly deals with the development of photochemical approaches to immobilize carbohydrates on surfaces for glycobiological studies. These approaches have been incorporated into a number of state-of-the-art nanobio-platforms, including carbohydrate microarrays, surface plasmon resonance (SPR), quartz crystal microbalance (QCM), atomic force microscopy (AFM), and glyconanomaterials. READ MORE

  4. 4. Macromolecules at Interfaces

    Author : Helén Larsericsdotter; Sven Oscarsson; Jos Buijs; Willem Norde; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Protein; Adsorption; Immobilization; Surface; Surface Plasmon Resonance; SPR; Mass Spectrometry; MS; Differential Scanning Calorimetry; DSC; FT ICR; Lysozyme; Bovine Serum Albumin; BSA; Myoglobin; Globular; Kemi; Chemistry; Kemi;

    Abstract : In this thesis, the structure and stability of globular proteins adsorbed onto nanometer-sized hydrophilic silica particles were investigated using differential scanning calorimetry (DSC), hydrogen/deuterium exchange (HDX), and mass spectrometry (MS). The adsorption process itself was characterized with fluorescence and absorption spectroscopy and surface plasmon resonance (SPR). READ MORE

  5. 5. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

    Author : Helena Nordström; Helena Danielson; Gregg Siegal; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

    Abstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE