Search for dissertations about: "Surface plasmon resonance SPR"
Showing result 6 - 10 of 73 swedish dissertations containing the words Surface plasmon resonance SPR.
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6. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology
Abstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE
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7. Studies of Glycosaminoglycan Interactions - Surface Immobilization Strategies and Biosensing Applications
Abstract : Many important biological functions of glycosaminoglycans (GAGs) have been highlighted in research literature during recent years. GAGs often serve as function-bearing structural elements in the extracellular matrix (ECM), but are also constituents of the cell membrane. GAGs take part in various biological mechanisms, e.g. READ MORE
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8. Towards specific quantification of exosomes using surface-based sensing
Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE
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9. Physical characterization of exosomes and other extracellular vesicles using surface-based sensing
Abstract : Extracellular vesicles (EVs) are hundred of nanometer sized particles secreted by almost all cell types. Exosomes are one type of EVs today intensively investigated due to the increased evidence suggesting that they play important roles as communicating vehicles in a broad range of physiological processes, pathological conditions and disease diagnostics. READ MORE
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10. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance
Abstract : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. READ MORE