Search for dissertations about: "Sven-christian Pawelzik"

Found 1 swedish dissertation containing the words Sven-christian Pawelzik.

  1. 1. Structure and Function of Microsomal Prostaglandin E Synthase-1

    Author : Sven-Christian Pawelzik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of inflammation, pain, and fever. READ MORE