Search for dissertations about: "Synaptic depression"

Showing result 1 - 5 of 32 swedish dissertations containing the words Synaptic depression.

  2. 1. Astrocyte-mediated short-term synaptic depression

    Author : My Andersson; Göteborgs universitet; []
    Keywords : glutamate; glia; plasticity; synapse; hippocampus;

    Abstract : Short-term synaptic plasticity, the activity-dependent regulation of synaptic efficacy that occurs in the timeframe of milliseconds to seconds, is a fundamental property of the synapse, mostly attributed to changes in release probability. These changes are commonly ascribed to intrinsic mechanisms in the presynaptic terminal and to different transmitters acting on the presynaptic terminal. READ MORE

  4. 2. Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor

    Author : Joakim Strandberg; Göteborgs universitet; []
    Keywords : AMPA receptor; Development; Glutamate; Hippocampus; Long-term depression; Long-term potentiation; NMDA receptor; Synaptic depression;

    Abstract : The glutamate synapse is by far the most common synapse in the brain and acts via postsynaptic AMPA, NMDA and mGlu receptors. During brain development there is a continuous production of these synapses where those partaking in activity resulting in neuronal activity are subsequently selected to establish an appropriate functional pattern of synaptic connectivity while those that do not are elimimated. READ MORE

  5. 3. Synaptic transmission and synaptic plasticity in the mouse striatum

    Author : Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. READ MORE

  6. 4. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Author : Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. READ MORE

  7. 5. Allosteric regulation of synaptic processes

    Author : Ranjita Dutta Roy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glutamatergic neurotransmission is of key importance for short-term and long-term plasticity in the hippocampus, a part of the medial temporal lobe which is responsible for processes of explicit semantic and spatial memory. Short-term plasticity is mainly regulated by the presynaptic neuron and long-term plasticity is to large parts regulated by the post-synaptic neuron. READ MORE