Search for dissertations about: "Synaptic integration"
Showing result 1 - 5 of 24 swedish dissertations containing the words Synaptic integration.
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1. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration
Abstract : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. READ MORE
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2. Synaptic Integration of Hippocampal Neurons Generated in the Adult Brain: Influence of a Pathological Environment
Abstract : The adult brain constantly produces new neurons from endogenous neural progenitor cells located in at least two regions, the subgranular zone (SGZ) in dentate gyrus of the hippocampus, and the subventricular zone (SVZ). Major efforts are underway to discover the functional significance of new neurons in the adult brain. READ MORE
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3. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair
Abstract : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. READ MORE
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4. Gene Therapy for Neurological Disorders
Abstract : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. READ MORE
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5. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity
Abstract : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. READ MORE