Search for dissertations about: "Synaptonemal complex"

Showing result 1 - 5 of 8 swedish dissertations containing the words Synaptonemal complex.

  2. 1. Meiotic chromosome segregation : molecular analysis of the synaptonemal complex

    Author : Li Yuan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Meiosis is a special type of cell division that produces haploid gametes from diploid parental cells. As such, meiosis stands at the gateway to sexual reproduction in most eukaryotic organisms. During meiosis, a complex, but tightly coordinated series of events occur. Homologous chromosomes come together and pair along their entire length. READ MORE

  4. 2. Molecular architecture of meiotic chromosomes

    Author : Ivana Novak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Meiosis; Chromosome architecture; Synaptonemal complex; Cohesin complex;

    Abstract : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. READ MORE

  5. 3. Aspects of the regulation of human sperm motility

    Author : Pär K G Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis I address some of the possible causes for oligozoospermia and low sperm motility, two factors that, singly or in combination, are often seen in cases of male subfertility. In the first study we evaluated the effect on human spermatozoa of the toxicity of compounds present in diesel exhaust. READ MORE

  6. 4. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis

    Author : Jeanette Pelttari Danielsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. READ MORE

  7. 5. Proteins influencing the integrity of meiotic chromosome dynamics

    Author : Mary-Rose Hoja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. READ MORE