Search for dissertations about: "Synucleinopathies"

Showing result 1 - 5 of 9 swedish dissertations containing the word Synucleinopathies.

2. 1. Oligodendroglial (dys)function in alpha-synucleinopathies

   Author : Carla Azevedo; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synucleinopathies; iPSCs; oligodendrocytes; alpha-synuclein; HLA; cell maturation; immunoproteasome;

   Abstract : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. READ MORE

4. 2. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

   Author : Edoardo Brandi; Neural plasticitet och reparation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

   Abstract : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. READ MORE

5. 3. Alpha-synuclein: pathology, peripheral expression, and environmental interactions

   Author : Caroline Haikal; Neural plasticitet och reparation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease PD ; alpha-synuclein; Bacterial amyloids; Synucleinopathies; Gastrointestinal GI tract; DMSO;

   Abstract : .... READ MORE

6. 4. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

   Author : Emma Brolin; Joakim Bergström; Anna Erlandsson; Martin Ingelsson; Arianna Bellucci; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson’s disease; synaptosome; SNARE complex; proximity ligation assay; extracellular vesicles;

   Abstract : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. READ MORE

7. 5. Development of specific monoclonal antibodies against different forms of alpha-synuclein as diagnostic tools for synucleinopathies

   Author : Nishant Narayanan Vaikath; Neural plasticitet och reparation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies(DLB) and multiple system atrophy (MSA), are a group of neurodegenerative disorders characterized by the abnormal accumulation of insoluble alpha-synuclein (α-syn) aggregates in the brain. The detection of α syn pathology has relied vastly on the use of several antibodies, which were mostly generated against different forms of α-syn. READ MORE