Search for dissertations about: "Systembiologi"

Showing result 1 - 5 of 272 swedish dissertations containing the word Systembiologi.

  2. 1. Systems and Network-based Approaches to Complex Metabolic Diseases

    Author : Muhammad Arif; Adil Mardinoglu; Thomas Sauter; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioteknologi; Biotechnology;

    Abstract : The future of healthcare is personalized medicine, in which disease treatments are tailored based on the individual characteristics of each patient. To reach that objective, we need to obtain a better understanding of diseases. READ MORE

  4. 2. On thermodynamic and kinetic constraints in autotrophic metabolism

    Author : Markus Janasch; Elton P. Hudson; Bas Teusink; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; autotrophic metabolism; cyanobacteria; microbial metabolic engineering; computational systems biology; biochemical thermodynamics; kinetic modelling; Bioteknologi; Biotechnology;

    Abstract : Earth has entered a new geological epoch, the Anthropocene, defined by humanity’s impact on the environment with increased emissions of CO2 due to burning of fossil resource as a major contributor. To ensure a sustainable future, humanity has to move towards a circular economy, where released CO2 is re-captured and turned into resources. READ MORE

  5. 3. Proteomic strategies for blood biomarker development in rare dystrophinopathies

    Author : Camilla Johansson; Cristina Al-Khalili Szigyarto; Ola Söderberg; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Duchenne muscular dystrophy; Becker muscular dystrophy; proteomics; affinity-proteomics; biomarkers; DIA-MS; SRM-MS; immunoassay; suspension bead arrays; Duchenne muskeldystrofi; Becker muskeldystrofi; proteomik; affinitetsproteomik; biomarkörer; DIA-MS; SRM-MS; immunoassay; suspension bead array; Biotechnology; Bioteknologi;

    Abstract : Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are two rare genetic disorders of the family dystrophinopathy. They are both caused by the lack of, or reduced production of, the protein dystrophin. READ MORE

  6. 4. Computational modelling in systems biology: from rewriting cell fates to detecting tumours

    Author : Emil Andersson; Centrum för miljö- och klimatvetenskap (CEC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Beräkningsmodeller; Systembiologi; Genreguleringsnätverk; Cellomprogrammering; Energilandskap; iPSC; Agentbaserad modellering; T-cellsutveckling; Maskininlärning; Tumördiagnostik; Computational modelling; Systems biology; Gene regulatory network; Cell reprogramming; Energy landscape; iPSC; Agent-based modelling; Multi-scale modelling; T-cell development; Machine learning; Tumour diagnostics;

    Abstract : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. READ MORE

  7. 5. Adaptations and constraints associated with autotrophy in microbial metabolism

    Author : Johannes Asplund Samuelsson; Elton P. Hudson; Adil Mardinoglu; Costas D. Maranas; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Autotrophy; Carbon fixation; CO2 fixation; Calvin cycle; CBB cycle; Bacteria; Archaea; Prokaryotes; Cyanobacteria; Synechocystis; E. coli; Comparative genomics; Metabolic engineering; Microbial metabolism; Machine learning; Systems biology; Ribosome profiling; Kinetic modeling; Enzyme kinetics; Metabolic models; Pathway enumeration; Biosynthesis pathways; Metabolomics; Metabolite concentrations; Thermodynamics; Autotrofi; Kolfixering; CO2-fixering; Calvincykeln; CBB-cykeln; Bakterier; Arkéer; Prokaryoter; Cyanobakterier; Synechocystis; E. coli; Jämförande genomik; Metabolisk ingenjörskonst; Mikrobiell metabolism; Maskininlärning; Systembiologi; Ribosomprofilering; Kinetisk modellering; Enzymkinetik; Metaboliska modeller; Syntesvägsuppräkning; Biosyntesvägar; Metabolomik; Metabolitkoncentrationer; Termodynamik; Bioteknologi; Biotechnology;

    Abstract : Carbon dioxide (CO2) emissions from human activities are driving climate change, but the pending crisis could be mitigated by a circular carbon economy where released CO2 is recycled into commodity chemicals. Autotrophic microbes can make a contribution by producing chemicals, such as biofuels, from CO2 and renewable energy. READ MORE