Search for dissertations about: "Systemic Inflammation"

Showing result 11 - 15 of 455 swedish dissertations containing the words Systemic Inflammation.

  2. 11. Genetic Contributions to Manifestations and Prognosis of Systemic Lupus Erythematosus

    Author : Sarah Reid; Dag Leonard; Timothy Niewold; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; genetics; cardiovascular disease; polygenic risk score; smoking; Medicinsk vetenskap; Medical Science;

    Abstract : Systemic lupus erythematosus (SLE) is a severe autoimmune disease with a multifactorial aetiology and an extremely heterogenous clinical picture. This thesis explores the impact of SLE genetic variants, through their cumulative effect or gene-environment interactions, on SLE manifestations and complications. READ MORE

  4. 12. Antinuclear and antiphospholipid antibodies versus disease manifestations and clinical outcomes in systemic lupus erythematosus

    Author : Martina Frodlund; Christopher Sjöwall; Jonas Wetterö; Thomas Skogh; Lene Dreyer; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Systemic lupus erythematosus (SLE) has an exceptionally heterogeneous clinical spectrum, ranging from mild disease limited to skin and joints to severe manifestations with renal disorder, central nervous system disease, severe cytopenias and thromboembolic events. Important clinical challenges include the prediction of disease flares and the identification of individuals that are likely to evolve severe disease with accrual of organ damage and worse prognosis. READ MORE

  5. 13. Skin fibrosis, internal organ involvement and auto antibodies in systemic sclerosis: longitudinal development and impact on survival

    Author : Roger Hesselstrand; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; proteoglycan; pulmonary hypertension; organ involvement; auto antibodies; survival; systemic sclerosis; prognosis;

    Abstract : Systemic sclerosis (SSc) is a connective tissue disease with a highly variable prognosis. Since new treatment strategies are emerging, there is a need for prognostic markers in order to help allocate patients to the optimal treatment. READ MORE

  6. 14. Studies on Neuropsychiatric Manifestations and Genetic Factors in Systemic Lupus Erythematosus

    Author : Andreas Jönsen; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Genetics; Systemic Lupus Erythematosus; Neuropsychiatric; rheumatology locomotion; Skelett; muskelsystem; reumatologi; muscle system;

    Abstract : Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. READ MORE

  7. 15. C-reactive protein (CRP) and anti-CRP autoantibodies in systemic lupus erythematosus : a study on the occurrence and clinical implications of anti-CRP antibodies and CRP-mediated complement activation

    Author : Christopher Sjöwall; Thomas Skogh; Johan Frostegård; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; complement activation; C-reactive protein; cytokines; immune complex; immunoregulation; opsonization; systemic lupus erythematosus; Rheumatology; Reumatologi;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of a wide range of autoantibodies, multiple organ involvement and by local formation or tissue deposition of immune complexes (ICs) in the inflamed organs. In contrast to most systemic inflammatory conditions, and despite raised levels of pro-inflammatory cytokines, SLE flares are rarely reflected by elevated C-reactive protein (CRP), an important acute-phase reactant in man with homologs in vertebrates and several invertebrates. READ MORE