Search for dissertations about: "Systems Biology"

Showing result 16 - 20 of 932 swedish dissertations containing the words Systems Biology.

  2. 16. Using systems genetics to explore the complexity of leaf shape variation in Populus tremula

    Author : Barbara Terebieniec; Nathaniel Street; Chung-Jui Tsai; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Populus; Arabidopsis; systems biology; systems genetics; spatial transcriptomics ST ; single nucleotide polymorphism SNP ; Genome wide associations study GWAS ; expression GWAS eGWAS ; molekylärbiologi; Molecular Biology;

    Abstract : Leaves are essential for sustaining humanity as they function as the energy and oxygen-producing organ of plants. Intensive research on physiological processes has contributed immensely to our understanding of the function of leaves. However, comparatively little is known about how leaf size and shape is determined. READ MORE

  4. 17. Metabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene Production

    Author : Gionata Scalcinati; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Systems Biology; Saccharomyces cerevisiae.; Evolutionary engineering; Metabolic Engineering; Microrefinery; Cell factory; Synthetic Biology;

    Abstract : Industrial biotechnology aims to develop robust “microbial cell factories”, to produce an array of added value chemicals presently dominated by petrochemical processes. The exploitation of an efficient microbial production as sustainable technology has an important impact for our society. READ MORE

  5. 18. Advancing systems biology of yeast through machine learning and comparative genomics

    Author : Le Yuan; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzyme turnover number; gene essentiality; horizontal gene transfer; machine learning; deep learning; yeast species;

    Abstract : Synthetic biology has played a pivotal role in accomplishing the production of high value commodities, pharmaceuticals, and bulk chemicals. Fueled by the breakthrough of synthetic biology and metabolic engineering, Saccharomyces cerevisiae and various other yeasts (such as Yarrowia lipolytica , Pichia pastoris ) have been proven to be promising microbial cell factories and are frequently used in scientific studies. READ MORE

  6. 19. From single-molecule sensing to extracellular vesicles in glioma cells under stress

    Author : Virginia Claudio; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteome; single molecule sensing; nanoplasmonics; surface plasmon resonance; exosomes; glioblastoma; extracellular vesicles; cellular stress; lipid composition;

    Abstract : This thesis describes the work I conducted in two different areas, namely biomolecular sensing and quantitative cell biology. The work in the former area was focused on the optimization of plasmonic metamaterials for sensing applications, and in the latter on the characterization of extracellular vesicles released by glioblastoma cells under stress conditions. READ MORE

  7. 20. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

    Author : Avlant Nilsson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

    Abstract : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. READ MORE