Search for dissertations about: "TβRI-ICD"

Found 4 swedish dissertations containing the word TβRI-ICD.

  2. 1. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Author : Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  4. 2. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Author : Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  5. 3. Non-canonical TGFb signaling pathways in prostate cancer

    Author : Jie Song; Marene Landström; Staffan Strömblad; Umeå universitet; []
    Keywords : TGFβ; TβRI; TRAF6; ubiquitination; APPL1; p85; AKT; PKCζ;

    Abstract : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. READ MORE

  6. 4. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival

    Author : Maria Ekman; Marene Landström; Carl-Henrik Heldin; Jonas Fuxe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta; cell migration; invasion; apoptosis; Smad7; APC; ATM; TRAF6; p53; PC3U; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. READ MORE