Search for dissertations about: "T Nilsson"

Showing result 11 - 15 of 92 swedish dissertations containing the words T Nilsson.

  1. 11. Characterization of secondary and therapy-related acute myeloid leukemia

    Author : Christer Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Secondary acute myeloid leukemia (s-AML) refers to patients with either therapy-related AML (t-AML), that is, AML after treatment with chemo- and/or radiation for a prior disease, or AML progressing from an antecedent hematologic disorder (AHD-AML), typically a myelodysplastic syndrome (MDS) or a myeloproliferative neoplasm. Patients with s-AML present with higher rates of adverse cytogenetic aberrations and higher frequencies of adverse mutations and, subsequently, respond worse to therapy, and have poorer outcome compared to de novo AML. READ MORE

  2. 12. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

    Author : Lars Nilsson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

    Abstract : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. READ MORE

  3. 13. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects

    Author : Gunnar Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Ewing s sarcoma; synovial sarcoma; translocation; fusion gene; fusion protein; diagnosis and prognosis;

    Abstract : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. READ MORE

  4. 14. Species interactions in streams - effects of predation, competition and ecosystem properties

    Author : Erika Nilsson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; behaviour; species abundance; stable isotopes; habitat complexity; niche width; niche overlap; competition; streams; predation;

    Abstract : Stream ecosystems are dynamic and they have an inherent environmental variability. Organisms that live in streams are adapted to the continuously changing environment and the presence or absence of species are determined by their environmental requirements, while abundance is most often affected by interactions, such as competition and predation, with other species that are found in the same habitat. READ MORE

  5. 15. Unifying first-principles and model approaches for strongly correlated materials : Interplay between long- and short-range correlations

    Author : Fredrik Nilsson; Matematisk fysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; first-principle methods; strongly correlated materials; GW approximation; cRPA; random-phase approximation; dynamical mean-field theory; GW DMFT; downfolding;

    Abstract : In materials with open 3$d$ and 4$f$ shells the valence electrons are relatively localized around the atoms which leads to large electron-electron correlations. These, so called strongly correlated materials, exhibit many intriguing properties such as high $T_c$ superconductivity, colossal magneto-resistance and heavy fermion behaviour. READ MORE