Search for dissertations about: "T Sera"

Showing result 1 - 5 of 72 swedish dissertations containing the words T Sera.

  2. 1. Immunological Studies using Human and Canine Model Disorders

    Author : Kerstin M. Ahlgren; Anna Lobell; Olle Kämpe; Kerstin Lindblad-Toh; Roland Jonsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; T cell; T helper cell; B cell; Autoantibodies; Interferon; Interleukin; Dogs; APS-1; Candida albicans; fungus; Immunologi; Immunology; Medicin; Medicine;

    Abstract : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. READ MORE

  4. 2. Dust mite allergens : cloning, characterisation and T-cell responses

    Author : Tove L J Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The number of allergens that have been cloned has increased dramatically during the last 10 years, and today, over 400 allergen sequences are available in the databases. In addition, at least 15 dust mite allergens have been characterised. READ MORE

  5. 3. Regulation of T-cell proliferation and B-CLL apoptosis by CD6 and FAS/FASL

    Author : Lydia Maria Osorio Fernández; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T-cell activation; CD6; B-CLL; apoptosis; Fas; FasL;

    Abstract : T-cell activation involves the interaction between the T-cell receptor (TCR) and the peptide/MHC complex presented on an antigen-presenting cell. However, this is not sufficient for the full development of T cell responses and co-stimulatory signals from accessory molecules are required. READ MORE

  6. 4. Specific autoimmunity in rheumatoid arthritis : T cells, antibodies and genetic regulation

    Author : Omri Snir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Complex interactions between genes and environmental factors may result in destruction of the body’s own cells and tissues by the immune system, i.e. autoimmunity. Rheumatoid arthritis (RA) is a chronic joint inflammation mediated by all arms of the immune system that can lead to tissue destruction and functional disabilities. READ MORE

  7. 5. Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice

    Author : Simon Guérard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and eventually invalidity if left untreated. READ MORE