Search for dissertations about: "T cell activation"

Showing result 16 - 20 of 711 swedish dissertations containing the words T cell activation.

  2. 16. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  4. 17. Human T-lymphocyte activation : interactions between lymphocytes and mitogenic or non-mitogenic lectins

    Author : Marie-Louise Dillner-Centerlind; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The aim of this investigation was to gain further insights in the mechanisms of T-lymphocyte activation by lectins. Interactions between the lectins and purified lymphocytes from human peripheral blood, were studied in the following respects: in vitro culture requirements for lectin induced DNA-synthesis, intercellular regulations of the mitogen response and binding of lectins to lymphocyte surface components. READ MORE

  5. 18. Plasma membrane order; the role of cholesterol and links to actin filaments

    Author : Jelena Dinic; Ingela Parmryd; Gerrit van Meer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane Organization; Lipid rafts; Actin; Laurdan; di-4-ANEPPDHQ; Cholesterol; T cell signaling; Colocalization; Generalized Polarization; Cell Biology; cellbiologi;

    Abstract : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. READ MORE

  6. 19. Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S

    Author : Maria Henriksson; Bengt Hallberg; Lars Rönnstrand; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Pseudomonas aeruginosa; ADP-ribosylation; GAP; Ras superfamily; NAD; ExoS; 14-3-3; Cellbiologi; Cell biology; Cellbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. It uses a type III secretion dependent mechanism to translocate toxic effector proteins directly into the eukaryotic cell. READ MORE

  7. 20. Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines

    Author : Anne-Marie T Ciupitu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : heat shock protein 70; vaccination; tumour antigens; in vivo protection; T cell activation; adjuvant; LCMV;

    Abstract : New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection was not mediated by the hsp70 itself, but by tumour-specific peptides bound to the molecule. READ MORE