Search for dissertations about: "T cell differentiation"

Showing result 16 - 20 of 256 swedish dissertations containing the words T cell differentiation.

  2. 16. To be or not to be, unraveling molecular mechanisms for lineage decisions in developing blood cells

    Author : Robert Månsson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; common lymphoid precursor CLP ; early B-cell factor 1 EBF1 ; B-cell; Stemcell; hematopoiesis; extracellulära vätskor; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : All hematopoietic cells originate from hematopoietic stem cells (HSC) residing in the BM. The process of differentiation, through which HSCs generate progenitors and subsequently mature blood cells has been extensively studied but many of the regulatory mechanisms involved remains elusive. READ MORE

  4. 17. Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis

    Author : Anna Staffas; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prognostic markers; AML; T-ALL; leukemia; FLT3; NPM1; ERG; BAALC; KRAS;

    Abstract : Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. However, patients with a certain subtype of leukemia (e.g. READ MORE

  5. 18. Molecular genetics of B- and T-lymphocyte development

    Author : Ingela Wikström; Dan Holmberg; Inga-Lill Mårtensson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphocyte development; Dmu protein; transcription factor; bHLH; E2-2; T cell; B cell; marginal zone; Medical genetics; Medicinsk genetik;

    Abstract : Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bone marrow and T cells in the thymus have several analogous features, and are tightly regulated processes. Even though there is an increasing amount of information concerning lymphopoiesis, a lot of questions remain. READ MORE

  6. 19. Studies of molecular events during peripheral B cell differentiation

    Author : Jens Wrammert; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; B cells; Differentiation;

    Abstract : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. READ MORE

  7. 20. Genetic networks dictating early lymphoid lineage decision events

    Author : Emma Smith; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; hematopoiesis; B-cell development; transcription; Notch; EBF; extracellulära vätskor;

    Abstract : Differentiation from hematopoietic stem cells to mature blood cells of different lineages is a continuous process that requires the coordinated activity of several stage and lineage specific transcription factors. These factors act in a transcriptional hierarchy and also in a combinatorial manner to establish the expression of the genes that comprise a specific differentiation program. READ MORE