Search for dissertations about: "T cell exhaustion"
Showing result 1 - 5 of 24 swedish dissertations containing the words T cell exhaustion.
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1. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside
Abstract : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. READ MORE
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2. CAR T cells for Immunotherapy of Cancer
Abstract : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. READ MORE
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3. Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis
Abstract : Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. READ MORE
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4. Single cell studies of human T cell function with applications for HIV-1
Abstract : T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, malignancies and chronic viral infections, such as HIV-1, eventually cause the T cells to become dysfunctional, resulting in a loss of control. READ MORE
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5. Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion
Abstract : Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and improvement of treatment options, even optimal therapy cannot prevent the impact of HIV on the human immune system. READ MORE