Search for dissertations about: "T cell inactivation"

Showing result 1 - 5 of 29 swedish dissertations containing the words T cell inactivation.

  1. 1. Notch signalling in carcinogenesis With special emphasis on T-cell lymphoma and colorectal cancer

    Author : Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Abstract : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. READ MORE

  2. 2. Regulatory mechanisms controlling T cell activity

    University dissertation from Department of Cell and Molecular Biology, Lund University

    Author : Anette Sundstedt; Lund University.; Lunds universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; T cell superantigen anergy interleukin-2 transcription factor cytotoxicity; serology; Immunology; Immunologi; serologi;

    Abstract : This thesis is based on work studying the immunoregulatory mechanisms that govern the balance between activation and inactivation of T lymphocytes. Most of the work has been carried out in an experimental system using a T cell receptor (TCR-Vb3) transgenic mouse strain to obtain a homogenous T-cell population and utilizing the properties of bacterial superantigens to induce T cell responses and unresponsiveness in vivo. READ MORE

  3. 3. p16INK4A and p15INK4B in senescence, immortalization and cancer : Gene transfer by adenovirus vectors

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Jonas Fuxe; Karolinska Institutet.; Karolinska Institutet.; [2001]

    Abstract : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. READ MORE

  4. 4. The immortalization process of T cells with focus on the regulation of telomere length and telomerase activity

    University dissertation from Umeå : Umeå university

    Author : Sofie Degerman; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; patologi; Pathology;

    Abstract : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. READ MORE

  5. 5. Studies of Experimental Bacterial Translocation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Stenbäck; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Intestinal barrier; short bowel syndrome; small bowel transplantation; mesenteric lymph nodes; gadolinium chloride; T cell inactivation; glutamine; phosphatidylcholine; rat; Thiry-Vella loop; Kirurgi; MEDICINE Surgery; MEDICIN Kirurgi;

    Abstract : One of the main obstacles to maintaining patients with short bowel syndrome on parenteral nutrition, or successfully transplanting these patients with a small bowel graft, is the many severe infections that occur. Evidence is accumulating that translocating bacteria from the patient’s bowel causes a significant part of these infections. READ MORE