Search for dissertations about: "T cell inactivation"

Showing result 16 - 20 of 34 swedish dissertations containing the words T cell inactivation.

  2. 16. Electrophysiology of pancreatic A-, B- and D-cells studied in intact mouse islets of Langerhans

    Author : Sven Göpel; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; somatostatin; glucagon; insulin; patch-clamp; membrane potential; Pancreatic islet; ion channel; diabetes; Physiology; Fysiologi;

    Abstract : Abstract The electrophysiological properties of insulin-secreting b-cells, glucagon-releasing a-cells and somatostation-producing d-cells in intact mouse pancreatic islets were investigated using the perforated patch whole-cell technique. It is demonstrated that it is possible to functionally identify the different cell types in situ. READ MORE

  4. 17. Exploring early development and regenerative medicine using CRISPR/Cas9

    Author : Nerges Winblad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : With their intrinsic capacity to self-renew and their potential to differentiate to specialized tissues, human embryonic stem cells (hESCs) have many applications in the fields of cell therapy and developmental biology. By applying clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) genome engineering on selected genes in hESCs, we are able to create cells with desired characteristics. READ MORE

  5. 18. Immune regulation within the central nervous system and its role in demyelinating diseases

    Author : Bao-Guo Xiao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are diseases of the central nervous system (CNS) characterized by perivascular mononuclear inflammation and oligodendrocyte loss with demyelination. However, it is still not clear whether the pathology in MS and EAE is due to neuroantigen-specific CD4+ T cell-mediated autoimmune responses and/or bystander myelin damage resulting from an inflammatory response. READ MORE

  6. 19. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway

    Author : Tord Jonson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SMAD4; PCR; FISH; cytogenetics; chromosome; pancreatic cancer; TGFB signaling; cytogenetik; Genetik; Genetics;

    Abstract : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. READ MORE

  7. 20. Immune Changes in Pregnancy : A Survey of some Immunological Variables in Normal and Complicated Pregnancies

    Author : Leif Skamris Matthiesen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The maternal systemic immune response during pregnancy is only fragmentarily understood. An adequate immune response to the gestational product is of vital importance for a successful pregnancy. READ MORE