Search for dissertations about: "T cell inactivation"

Showing result 6 - 10 of 34 swedish dissertations containing the words T cell inactivation.

  2. 6. Studies of Experimental Bacterial Translocation

    Author : Anders Stenbäck; Cecilia Johnsson; Staffan Meurling; Bengt Jeppsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Intestinal barrier; short bowel syndrome; small bowel transplantation; mesenteric lymph nodes; gadolinium chloride; T cell inactivation; glutamine; phosphatidylcholine; rat; Thiry-Vella loop; Kirurgi; Surgery; Kirurgi;

    Abstract : One of the main obstacles to maintaining patients with short bowel syndrome on parenteral nutrition, or successfully transplanting these patients with a small bowel graft, is the many severe infections that occur. Evidence is accumulating that translocating bacteria from the patient’s bowel causes a significant part of these infections. READ MORE

  4. 7. Regulation of tubulin heterodimer partitioning during interphase and mitosis

    Author : Per Holmfeldt; Martin Gullberg; Pontus Aspenström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; microtubule; mitotic spindle; signal transduction; phosphorylation; cancer; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The microtubule cytoskeleton, which consists of dynamic polymers of alpha/beta tubulin heterodimers, organizes the cytoplasm and is essential for chromosome segregation during mitosis. My thesis addresses the significance and potential interplay between four distinct microtubule-regulatory proteins. READ MORE

  5. 8. Mechanisms of leukemia-induced immunosuppression

    Author : Johan Aurelius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Abstract : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. READ MORE

  6. 9. Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways

    Author : Maria Kraft; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokines; apoptosis; cell cycle; c-Kit; Flt3; Flt3-ITD; Akt; Bcl-2; FoxO3; mouse; hematopoiesis; progenitor;

    Abstract : Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. READ MORE

  7. 10. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells

    Author : Christina Seitz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). READ MORE