Search for dissertations about: "T cell signaling"

Showing result 16 - 20 of 261 swedish dissertations containing the words T cell signaling.

  2. 16. Ca2+ fluxes and insulin action in cardiac and skeletal muscles

    Author : Johanna T Lanner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity and type 2 diabetes are major and rapidly increasing health problems in society. They are associated with several life-threatening conditions, including heart and renal failure, and damage to the nervous system. An inability of cells to respond normally to insulin, insulin resistance, is a key feature in obesity and type 2 diabetes. READ MORE

  4. 17. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

    Author : Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

    Abstract : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. READ MORE

  5. 18. Smoking and T cell co-stimulation in rheumatoid arthritis

    Author : Caroline Wasén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; CD8 T cell; programmed cell death-1; programmed cell death-1 ligand 1; smoking; microRNA;

    Abstract : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. READ MORE

  6. 19. Paracrine and autocrine functions of PDGF in malignant disease

    Author : Tobias Sjöblom; Lars Holmgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. READ MORE

  7. 20. Thymic Stroma and T Cell Development. Impacts of Retinoic Acid Signaling

    Author : Kerstin Wendland; Slemhinnans immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thymus; Thymic epithelial cells; Retinoic acid; T cell development; Stromal Cells;

    Abstract : The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to the exit of mature naive T cells. READ MORE