Search for dissertations about: "T cells"

Showing result 21 - 25 of 2065 swedish dissertations containing the words T cells.

  2. 21. The leukocyte complexity and mutational landscape of periampullary adenocarcinoma. Morphology matters

    Author : Sebastian Lundgren; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; periampullary adenocarcinoma; pancreatic cancer; immune microenviroment; prognosis; macrophages; natural killer cells; natural killer T cells; T cells; B cells;

    Abstract : Background: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. READ MORE

  4. 22. On the role of nitric oxide in bladder cancer and renal cell carcinoma

    Author : Olof T Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : urogenital tract; renal cell; transitional cell; carcinoma; nitric oxide; nitric oxide synthase; cytokines; apoptosis; BCG; cystitis;

    Abstract : The role of nitric oxide (NO) in tumour biology is unclear. There are conflicting reports in the literature whether NO will promote or inhibit tumour growth. The aim of the present thesis was to investigate the role of NO in bladder cancer and renal cell carcinoma. READ MORE

  5. 23. Measurement of sensitivity to DNA damaging agents

    Author : Sherin T Mathew; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Abstract : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. READ MORE

  6. 24. Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines

    Author : Anne-Marie T Ciupitu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : heat shock protein 70; vaccination; tumour antigens; in vivo protection; T cell activation; adjuvant; LCMV;

    Abstract : New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection was not mediated by the hsp70 itself, but by tumour-specific peptides bound to the molecule. READ MORE

  7. 25. Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation

    Author : Joachim T. Siaw; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; ALK; 11q.; DLG2; SP1; differentiation; crizotinib; ceritinib; brigatinib;

    Abstract : Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. READ MORE