Search for dissertations about: "T-antigen"
Showing result 1 - 5 of 21 swedish dissertations containing the word T-antigen.
-
1. DNA and protein interactions of mouse polyomavirus large T antigen
Abstract : Polyomaviruses require dividing cells to multiply. The regulatory genes express proteins, theT-antigens, necessary for this to occur. Large T-antigen (LT), is a phosphoprotein withmultiple intrinsic activities, e.g. READ MORE
-
2. Mouse polyomavirus large T-antigen : DNA-binding and related activities
Abstract : .... READ MORE
-
3. Studies on the Molecular Biology of the Mouse Pneumotropic Polyomavirus
Abstract : The Murine Pneumotropic Virus (MPtV), in contrast to the other MurinePolyomavirus (MPyV), appears to be non-tumourigenic in its natural host. Instead, MPtV causes acute pneumonia and can serve as a model in studies of polyomavirus-induced disease. In initial experiments, MPtV large T-antigen (LT) was expressed in a heterologous system. READ MORE
-
4. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing
Abstract : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). READ MORE
-
5. Persistence of polyomavirus : versus immunity to polyoma tumors
Abstract : The aim of this thesis was to understand the role of different specific immune effectors with regard to polyomavirus persistence and polyomavirus induced tumor development. Furthermore, an MHC class I restricted short viral peptide was identified as a target for polyomavirus specific recognition of polyoma tumor cells. READ MORE