Search for dissertations about: "T-cell competition"

Showing result 1 - 5 of 7 swedish dissertations containing the words T-cell competition.

  2. 1. T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses

    Author : Per Grufman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CTL; Dendritic cells; Immunodominance; T-cell competition; IL- 12;

    Abstract : Immunodominance is a process in which the immune response focuses on one or a few of all potential epitopes that exists within an antigen. The mechanisms for immunodominance have not yet been determined. READ MORE

  4. 2. Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes

    Author : Cheng-Hong Wei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this study is to investigate the role of the affinity of peptide:MHC/TCR interaction in the regulation of T cell activation, death and repertoire selection. Three aspects pertinent for our understanding of this issue have been analyzed. READ MORE

  5. 3. Modelling T helper cell activation and development

    Author : Andreas Jansson; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; T cells; mathematical models; differentiation; computer simulation; mathematical models; cellular signal transduction; Bioinformatics; Bioinformatik; Natural sciences; Naturvetenskap; Technology; Teknik;

    Abstract : T helper (Th) cell activation and development is one of the most critical events in regulating the adaptive immune response. Understanding its regulation could be of great therapeutical value as many severe diseases are associated with failure in controlling T cell activation and development. READ MORE

  6. 4. Epstein-Barr virus latency in vivo and in vitro

    Author : Jie-Zhi Zou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis, I studied 1) The latency situation of Epstein- Barr virus (EBV) in bone marrow transplanted (BMT) patients and healthy virus carriers. 2) The role of EBNA1 and cellular transcriptional factors Oct and Grg/TLE family in EBV latency switch. READ MORE

  7. 5. Regulation of the germinal center response by T follicular helper cells and type I interferons

    Author : Madelene Dahlgren; Adaptivt immunförsvar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Germinal Center; T follicular helper cell; type I interferon; dendritic cell; adjuvant; differentiation; IgG;

    Abstract : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. READ MORE