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Showing result 1 - 5 of 408 swedish dissertations matching the above criteria.

  2. 1. Early events in T cell development

    Author : Karin Leandersson; Malmö Cancerimmunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; pTalpha; gammadelta T cell; alphabeta T cell; development; thymus; thymocyte; serology; transplantation; Immunologi; serologi;

    Abstract : T cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). READ MORE

  4. 2. Glucocorticoid in T cell differentiation

    Author : Yintong Xue; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thymocytes differentiate into mature T cells with an immunological restriction for self major histocompatibility complex (MHC) antigens. Cells that do not recognize self MHC expressed on thymic epithelial cells (TEC) die by a rapid induction of apoptosis (default selection). READ MORE

  5. 3. Extrathymic T cell receptor gene rearrangement in human alimentary tract

    Author : Anna Bas; Marie-Louise Hammarström; Sten Hammarström; Adrian Hayday; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; T cell maturation; recombination activating gene; preTα; human intestinal mucosa; intraepithelial lymphocytes; lamina propria lymphocytes; nasopharyngeal tonsil; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Abstract : T lymphocytes regulate the initiation, duration, and magnitude of adaptive immune responses and function as effector cells in cell mediated immunity. To become immunologically competent they must generate functional antigen receptors. This process takes place in the thymus and requires somatic recombination of T cell receptor (TCR) genes. READ MORE

  6. 4. Thrombospondin 1, an autocrine regulator in T cell adhesion and migration

    Author : ShuShun Li; Karl-Gösta Sundqvist; Jan Holgersson; Claes Dahlgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; T cell; adhesion; migration; thrombospondin; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Lymphocytes, the principal cells of the immune system, perform the immune function throughout the body by their unique capacity to circulate in blood stream and lymphatic vessels and migrate in lymphoid and non-lymphoid tissues. The mechanisms regulating lymphocyte adhesion and migration, interactions with cells and components within the extracellular matrix are not fully understood. READ MORE

  7. 5. Aspects of T cell development contributing to autoimmunity

    Author : Maria Carlsén; Diabetes - immunovirologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Abstract : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. READ MORE