Search for dissertations about: "T-cell recruitment"

Showing result 1 - 5 of 73 swedish dissertations containing the words T-cell recruitment.

2. 1. T-cell responses to Helicobacter pylori in humans and a possible role of regulatory T cells

   Author : Anna Lundgren; Göteborgs universitet; []
   Keywords : Helicobacter pylori; mucosal immunology; stomach; duodenum; asymptomatic; duodenal ulcer; gastric adenocarcinoma; T cells; regulatory T cells; dendritic cells; T-cell recruitment;

   Abstract : Helicobacter pylori colonize the stomach and areas of gastric metaplasia in the duodenum. The bacteria induce both local and systemic immune responses, but despite this, the infection normally persists for life and causes chronic gastritis in all infected subjects and peptic ulcers or gastric cancer in 10-20% of infected individuals. READ MORE

4. 2. T Cell recruitment in human Helicobacter pylori associated diseases

   Author : Karin Enarsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Helicobacter pylori (Hp) infection is associated with pronounced infiltration of granulocytes and lymphocytes into the gastric mucosa, resulting in active chronic gastritis that may develop into duodenal ulcer disease or gastric adenocarcinoma (GC). Infiltrating T cells play a major role in the pathology of these diseases, but the signals involved in recruitment of T cells from blood to H. READ MORE

5. 3. EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA

   Author : Hanna Stenstad; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; Immunology; serology; homing; intestine; GALT; chemokine receptor; lymphocyte; serologi;

   Abstract : The intestinal mucosa, including the intestinal epithelium and underlying lamina propria (LP), contains a large number of effector/memory T cells that are thought to play a central role in the generation and maintenance of mucosal immune responses and in maintaining mucosal integrity. The work in this thesis investigates the mechanisms regulating effector T cell recruitment to the small intestinal mucosa focusing on the role of chemokine receptors in this process. READ MORE

6. 4. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

   Author : Malin Bjursten; Göteborgs universitet; []
   Keywords : colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

   Abstract : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. READ MORE

7. 5. Regulation of T cell effector functions in the intestinal mucosa

   Author : Petra Holmkvist; Slemhinnans immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cells; memory; intestine; cytokines; differentiation; IL-18; inflammation; antigen presentation;

   Abstract : T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. READ MORE