Search for dissertations about: "T-cells In rheumatoid arthritis"

Showing result 1 - 5 of 90 swedish dissertations containing the words T-cells In rheumatoid arthritis.

2. 1. T cells and chemokines in rheumatoid arthritis

   Author : Jonathan Aldridge; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; CD4 T cells; chemokines; disease activity; biomarker; CTLA-4Ig;

   Abstract : In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early rheumatoid arthritis (eRA). We also compared the effect of different biological treatments on both T cell subset proportions and chemokine levels. READ MORE

4. 2. Atherosclerotic cardiovascular disease in rheumatoid arthritis : aspects of pathogenesis and risk

   Author : Bengt Wahlin; Solveig Wållberg-Jonsson; Anna Södergren; Anders Bengtsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; inflammation; atherosclerosis; cardiovascular disease; risk estimation; cytomegalovirus; T-cells; bone turnover; osteoprotegerin; osteocalcin; Medicine; medicin;

   Abstract : Patients with rheumatoid arthritis (RA) have an increased prevalence and severity of atherosclerosis, and a corresponding increased risk of cardiovascular disease. The mechanisms causing this are not well elucidated, but both traditional cardiovascular risk factors and RA-associated factors have been associated with atherosclerosis and increased risk of cardiovascular events in patients with RA. READ MORE

5. 3. Functional studies of T-cells in rheumatoid arthritis

   Author : Louise Berg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : T-cells; Rheumatoid arthritis; inflammation; cytokines; collagen type II; immunomodulation;

   Abstract : Rheumatoid arthritis (RA) is a systemic inflammatory disease with autoimmune features primarily affecting the joints. The etiology of RA is largely unknown but involvement of the immune system in the disease process is evident from the infiltration of leukocytes into the joint, and by the production of proinflammatory cytokines, chemokines and proteases, mainly by macrophages. READ MORE

6. 4. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

   Author : Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

   Abstract : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. READ MORE

7. 5. Rho-GTPases in Rheumatoid Arthritis

   Author : Eric Malmhäll-Bah; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-GTPases; rheumatoid arthritis; innate immunity; adaptive immunity; RA treatment;

   Abstract : The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase enzymes catalyzing guanosine triphospate (GTP) to guanosine diphospate (GDP), have a detrimental role in many diseases including RA. READ MORE