Search for dissertations about: "T-lymphocyte"

Showing result 21 - 25 of 91 swedish dissertations containing the word T-lymphocyte.

  2. 21. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  4. 22. Lymphoid development and function in MHC class I deficient mice

    Author : Sofia Freland; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MHC class I; T cell selection; cytotoxic T lymphocyte; antigen presentation; MHC class I deficient mice; NK cell; tumor growth;

    Abstract : MHC class I molecules present short peptide fragments, derived from proteins synthesized in the cytosol, to specific CTL. The MHC class I molecule is a heterotrimer encompassed of a polymorphic transmembrane glycoprotein (heavy chain), ß2-microglobulin (ß2m), and a peptide. READ MORE

  5. 23. Immune mechanisms in atherosclerosis : the role of T cells in murine models of atherosclerosis

    Author : Xinghua Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; inflammation; murine models; low density lipoprotein; lipoprotein oxidation; T lymphocyte; T-cell antigen receptors; hypercholesterolemia; autoantibodies; T-cell cytokines; immunization; cardiolipin;

    Abstract : Atherosclerosis is an inflammatory disease. Much interest has been focused on the immune responses in the pathogenesis of the disease. The role of T cells in the development of atherosclerosis was therefore investigated in murine models in this study. READ MORE

  6. 24. Chemokines and Integrins in Lymphocyte Development and Localization

    Author : Jan Marsal; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; serology; Immunology; homing; development; IEL; lymphocytes; chemokines; integrins;

    Abstract : The small intestine contains a large number of T lymphocytes within the single-layered epithelium that separates the gut lumen from the lamina propria. These intraepithelial T lymphocytes have potent cytolytic and immunoregulatory capacities, thought to be important for fighting infections, neoplastic growth, and sustaining epithelial integrity. READ MORE

  7. 25. Regulatory T cells : molecular and clinical aspects

    Author : Malin E Winerdal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the immune system’s tug of war with cancer, tolerance mechanisms by which the tumor can control anti-tumor immune responses play a central role in determining the outcome. Regulatory T cells (Treg) induced in the thymus or the periphery, represent one such tolerance mechanism that potentially can be exploited by developing tumors. READ MORE