Search for dissertations about: "T3SS inhibitors"

Showing result 1 - 5 of 6 swedish dissertations containing the words T3SS inhibitors.

2. 1. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

   Author : Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

   Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE

4. 2. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach

   Author : Sara Garbom; Hans Wolf-Watz; Dan Andersson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Yersinia; T3SS; virulence associated genes; VagH; HemK PrmC; Release factors; small molecular inhibitors; HTS; Medical microbiology; Medicinsk mikrobiologi;

   Abstract : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. READ MORE

5. 3. Regulation of the multi-functional protein YscU in assembly of the Yersinia type III secretion injectisome

   Author : Ho Ngoc Hoang Oanh; Magnus Wolf-Watz; Anna Linusson Jonsson; Maria Sunnerhagen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system T3SS ; injectisome; Yersinia pseudotuberculosis; inhibitors; Yops; YscU; YscP; YscI; disorder-to-order transition; nuclear magnetic resonance NMR ; circular dichroism CD ; isothermal titration calorimetry ITC ; biologisk kemi; biological chemistry;

   Abstract : Yersinia pseudotuberculosis is a Gram-negative zoonotic pathogenic bacterium causing gastroenteritis in human and animals. It shares a conserved virulence plasmid encoding for a needle-like secretion machinery, or type III secretion system, which can be found in other pathogenic Gram-negative bacteria. READ MORE

6. 4. Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa

   Author : Michael Saleeb; Mikael Elofsson; Anna Linusson Jonsson; Andreas Kirschning; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibacterials; antibiotics; small molecules; natural products; benzofuran; dihydrobenzofuran; the type III secretion system; Pseudomonas aeruginosa; Chlamydia trachomatis; phenotypic screening; high-throughput screening; surface plasmon resonance; drug discovery; bacterial toxins; enzyme inhibitors; organisk kemi; Organic Chemistry;

   Abstract : Antibiotic resistance has evolved significantly to become one of the serious threats to public health today. Yet, the pipeline of new antibiotics is drying up and is lagging behind the challenging needs. READ MORE

7. 5. Infection biology of Chlamydia pneumoniae

   Author : Leslie Bailey; Sven Bergström; Peter Nordström; Anders Waldenström; Kenneth Fields; Umeå universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Chlamydia pneumoniae; Type three secretion system; Bone; Medicine; Medicin;

   Abstract : There are two main human pathogens in the family of Chlamydiaceae. Different serovars of Chlamydia trachomatis cause sexually-transmitted disease and eye infections whereas C. pneumoniae (TWAR) is a common cause of community-acquired respiratory infection. READ MORE