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Showing result 1 - 5 of 28 swedish dissertations matching the above criteria.

2. 1. Molecular mechanism of plasmid copy number control in Yersinia

   Author : Tifaine Héchard; Helen Wang; Javier Pizarro-Cerda; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; plasmid copy number; T3SS; infection; ddPCR; Mikrobiologi; Microbiology;

   Abstract : The ability of pathogenic bacteria to cause disease depends on various virulence mechanisms. The three pathogenic species of Yersinia use a type III secretion system (T3SS) to translocate effector proteins into host cells and disrupt the immune system. This T3SS is encoded on a 70kb, low-copy, virulence plasmid. READ MORE

4. 2. YopD translocator function in Yersinia pseudotuberculosis type III secretion

   Author : Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
   Keywords : Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

   Abstract : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. READ MORE

5. 3. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

   Author : Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

   Abstract : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. READ MORE

6. 4. Controlling substrate export by the Ysc-Yop type III secretion system in Yersinia

   Author : Ayad Amer; Matthew Francis; David L. Gally; Umeå universitet; []
   Keywords : Y. pseudotuberculosis; T3SS; YscX; YopD; assembly; translation control; temporal secretion.; mikrobiologi; Microbiology;

   Abstract : Several pathogenic Gram-negative bacteria invest in sophisticated type III secretion systems (T3SS) to incapacitate their eukaryotic hosts. T3SSs can secrete protein cargo outside the bacterial cell and also target many of them into the eukaryotic cell interior. READ MORE

7. 5. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue

   Author : A. K. M. Firoj Mahmud; Maria Fällman; Matthew S. Francis; Javier Pizarro-Cerda; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; RpoN; T3SS; RNA-Seq; Biofilm; Transcription; Yersinia; Data analysis; ChIP-Seq; biology; biologi;

   Abstract : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. READ MORE