Search for dissertations about: "TAD"
Showing result 6 - 10 of 18 swedish dissertations containing the word TAD.
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6. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1
Abstract : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. READ MORE
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7. Towards trustworthy intelligent vehicle technology development
Abstract : This thesis addresses the unresolved issues of responsibility and accountability in autonomous vehicle (AV) development, advocating for human-centred approaches to enhance trustworthiness. While AVs hold the potential for improved safety, mobility, and environmental impact, poorly designed algorithms pose risks, leading to public distrust. READ MORE
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8. Population-based analyses of incidence, prognostic determinants and outcome of aortic dissection
Abstract : Background: Aortic dissection (AD) is a potentially life-threatening disease caused by a tear in the innermost layer of the aortic wall, the intima, resulting in blood flow between the layers of the aortic vessel wall. Main risk factors are hypertension, male sex and smoking. READ MORE
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9. Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
Abstract : Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated expression of MYC is present in a wide range of human tumors including Burkitt´s Lymphoma, neuroblastoma, medulloblastoma, colon cancer and glioblastoma. READ MORE
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10. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia
Abstract : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). READ MORE