Search for dissertations about: "TCDD"

Showing result 6 - 10 of 35 swedish dissertations containing the word TCDD.

  2. 6. Disruption of vitamin A metabolism by dioxin

    Author : Pi Högberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TCDD; dioxin; vitamin A; retinoic acid; cellular retinol-binding protein; bone;

    Abstract : Vitamin A (retinoids) is a nutrient that plays a central role in development and remains essential for cell growth and differentiation throughout life. Dioxins are polychlorinated organic pollutants known to negatively affect the storage and body clearance of retinoids. READ MORE

  4. 7. Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model

    Author : Sara Brunnberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin Ah Receptor; Arnt; TCDD; gene expression; reproductive tract; bone; heart;

    Abstract : The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to those considered tolerable. The foetus and newborn infant are considered as a particular risk group. READ MORE

  5. 8. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A storage in rat hepatic stellate cells

    Author : Annika Hanberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin; TCDD; vitamin A; retinoids; lecithin:retinol acyltransferase; absorption; stellate celL hepatic vitamin A accumulation; intestinal lymph collectionDoctoral Thesis 1996 Annika Hanberg;

    Abstract : The polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), popularly called dioxins, are persistent pollutants with widespread occurrence in the environment as well as in human food and tissues. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, as well as other dioxin-like compounds induce a broad spectrum of biochemical and toxic effects, many of which occur at extremely low doses or concentrations. READ MORE

  6. 9. Studies on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A homeostasis

    Author : Charlotte Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TCDD; dioxin; vitamin A; retinoic acid; lecithin:retinol acyltransferase; retinyl ester hydrolysis; retinol-binding protein; kidney; lymph; stellate cell; kinetics; model-based compartmental analysis;

    Abstract : Vitamin A (retinoids) is needed for normal vision, growth, reproduction, cell differentiation, embryonic development, and immune function. Retinoids exert their functions in the same way as classical hormones, as transcription factors acting via nuclear receptors. READ MORE

  7. 10. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls

    Author : Yvonne Bager; Karolinska Institutet; Karolinska Institutet; []
    Keywords : gap junctional intercellular communication; phosphorylation; tumour promotion; alteredhepatic foci; rat liver; potency; PCBs; TCDD.Doctoral Thesis Yvonne Bager;

    Abstract : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). READ MORE