Search for dissertations about: "TCF4"
Showing result 1 - 5 of 10 swedish dissertations containing the word TCF4.
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1. Fuchs’ endothelial corneal dystrophy : Genetic aetiology and as a risk factor in cataract surgery
Abstract : Fuchs’ endothelial corneal dystrophy (FECD) is a bilateral, often hereditary degenerative corneal disease, in which the disrupted endothelial cell function causes corneal swelling and reduced vision. An early clinical sign of FECD is corneal guttata, an irregularity of the endothelial layer. READ MORE
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2. Genetics, epigenetics and functional mechanisms in inherited corneal and retinal dystrophies
Abstract : Inherited eye disorders (IED) are groups of genetically and clinically heterogenous conditions affecting different tissues in the eye. IED are most often progressive with reduced vision or legal blindness as outcome. READ MORE
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3. Functional genomics at the interface of protein expression and biophysical analysis
Abstract : Protein characterization is central to any functional genomics effort, hence protein expression and purification play fundamental roles in these initiatives. In this study strategies for protein expression in E. coli were analysed, and several parameters were investigated respect to high-level expression of functional proteins. READ MORE
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4. Regulation of chromatin transitions in the 3D architecture of the nucleus
Abstract : The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation capture assay (4C) and Chromatin in situ Proximity (ChrISP) technique to uncover an inter-chromosomal chromatin fiber interactome comprising both transcriptionally active circadian genes and repressed lamina-associated domains (LADs). READ MORE
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5. Functional studies of deubiquitinating enzymes
Abstract : The attachment of ubiquitin to substrate proteins is a key process in regulating cellular events such as cell cycle progression, signal transduction, differentiation, apoptosis, and the clearance of misfolded or aberrant proteins. Like other post-translational modifications, ubiquitination is also reversible. READ MORE