Search for dissertations about: "TCF7L2"
Showing result 16 - 20 of 26 swedish dissertations containing the word TCF7L2.
-
16. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Abstract : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. READ MORE
-
17. Genetic Studies of Alzheimer's Disease
Abstract : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. READ MORE
-
18. Nutritional and dysmetabolic factors with potential impact on type 2 diabetes : epidemiological and molecular studies
Abstract : Diabetes is a group of diseases characterized by hyperglycaemia. Type 2 diabetes encompasses 85-95% of all diabetes with a prevalence that is expected to increase worldwide. READ MORE
-
19. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
Abstract : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). READ MORE
-
20. Optimizing Exposome-wide Assessments in Cardiometabolic Risk
Abstract : This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. READ MORE