Search for dissertations about: "TCR"

Showing result 16 - 20 of 173 swedish dissertations containing the word TCR.

  2. 16. Investigation of genetic factors involved in colorectal cancer predisposition

    Author : Tatjana Djureinovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : colorectal cancer CRC ; hereditary colorectal cancer HCRC ; two-close relatives TCR ; linkage analysis; case-control;

    Abstract : Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the western world. Several hereditary CRC predisposing syndromes have been described and their genetic component has been elucidated. Taken together, these syndromes account for at most 5% of all CRC cases. READ MORE

  4. 17. Inflammatory mechansims in pulmonary sarcoidosis

    Author : Mary Berlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adhesion molecules; alveolitis; bronchoalveolar lavage; bronchial hyperreactivity; extracellular matrix molecules; extrinsic allergic alveolitis; fibrosis; HLA-DR; sarcoidosis; TCR;

    Abstract : Pulmonary sarcoidosis is an inflammatory disorder of unknown aetiology, characterised by an accumulation of CD4+ T-cells in the alveolar compartment and by granuloma formation and varying degrees of interstitial fibrosis. The initial clinical presentation may either be acute with fever, malaise, arthritis and/or erythema nodosum or insidious with cough, dyspnea, tiredness, and loss of weight. READ MORE

  5. 18. Natural specific T cell immunity in patients with B-cell chronic lymphocytic leukaemia (B-CLL) : (A clinical and immunological study)

    Author : Mohammad Reza Rezvany; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B-CLL; TCR usage; clonality; natural T cell immunity; costimulatory molecules; dendritic cells; cytokines; tumor derived VH-CDR3.;

    Abstract : Analysis of TCRBV (T-cell receptor B variable) gene usage of the T cell repertoire in patients with B cell chronic lymphocytic leukaemia (B-CLL) and age-matched healthy control donors showed that major perturbations were more frequently seen in the CD4+ T cell subset than in CD8 population. Analysis of the CDR3 length polymorphism revealed a significantly higher degree of clonality within the CD4+ and CD8+ T cell repertoire of patients as compared to the normal control population. READ MORE

  6. 19. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Author : Karin Rödström; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Abstract : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. READ MORE

  7. 20. The influence of adhesion molecules on binding and protein organization in cell contacts

    Author : Tommy Dam; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; T cell; SLBs; Calcium Signaling; TIRF microscopy; Two-Dimensional affinity; Protein Segregation; Protein Organization; Protein Height;

    Abstract : Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. READ MORE