Search for dissertations about: "TGFβ"

Showing result 1 - 5 of 49 swedish dissertations containing the word TGFβ.

  1. 1. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    University dissertation from Umeå : Umeå University

    Author : Shyam Kumar Gudey; Umeå universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; patologi; Pathology;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  2. 2. TGFβ and LXR signaling in hepatocellular carcinoma

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Claudia Bellomo; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE

  3. 3. Gene regulation by different proteins of TGFβ superfamily

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Varun Maturi; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

    Abstract : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. READ MORE

  4. 4. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    University dissertation from Umeå : Umeå University

    Author : Reshma Sundar; Umeå universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  5. 5. Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Panagiotis Papoutsoglou; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; signal transduction; long non-coding RNAs; ADP-ribosylation; transcriptional regulation; chromatin remodeling; Medicinsk vetenskap; Medical Science;

    Abstract : Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. READ MORE