Search for dissertations about: "TGFβ"

Showing result 11 - 15 of 65 swedish dissertations containing the word TGFβ.

  2. 11. Non-canonical TGFb signaling pathways in prostate cancer

    Author : Jie Song; Marene Landström; Staffan Strömblad; Umeå universitet; []
    Keywords : TGFβ; TβRI; TRAF6; ubiquitination; APPL1; p85; AKT; PKCζ;

    Abstract : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. READ MORE

  4. 12. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    Author : Merima Mehić; Paraskevi Heldin; Carl-Henrik Heldin; Liliana Schaefer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Abstract : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. READ MORE

  5. 13. The control of growth and metabolism in Caenorhabditis elegans

    Author : Josefin Friberg; Simon Tuck; Cathy Savage-Dunn; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TGFβ; insulin; collagen; p70 S6K; metabolism; growth; dauer; Caenorhabditis elegans; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The control of growth is a poorly understood aspect of animal development. This thesis focuses on body size regulation in Caenorhabditis elegans, and in particular, how worms grow to a certain size. In C. elegans, a key regulator of size is the TGFβ homologue DBL-1. READ MORE

  6. 14. Inhibition of WNT5A Signaling and Function in Malignant Melanoma

    Author : Rickard Linnskog; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WNT5A; Malignant Melanoma; Migration; Invasion; TGFβ; IL-6; p38-MAPK;

    Abstract : The life-threatening disease of malignant melanoma is one of the fastest growing forms of cancer, affecting an estimated number of 200,000 patients worldwide every year. Although highly curable if detected early, once the melanoma has metastasized there are few treatment options and a median survival rate of only 6-9 months. READ MORE

  7. 15. Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts

    Author : Lizbet Todorova; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Proteoglycans; Lung fibroblasts; Collagen; Airway remodeling; TGFβ; Glucocorticoids; Combination therapy.; β2-agonist; MMPs;

    Abstract : Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. READ MORE