Search for dissertations about: "TGFβ"

Showing result 16 - 20 of 65 swedish dissertations containing the word TGFβ.

  2. 16. TGFβ Signal Transduction in Endothelial Cells

    Author : Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. READ MORE

  4. 17. Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

    Author : Helena Porsch; Paraskevi Heldin; Véronique Orian-Rousseau; Uppsala universitet; []
    Keywords : extracellular matrix; growth factor; hyaluronan synthase; hyaluronidase; epithelial-mesenchymal transition; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. READ MORE

  5. 18. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway

    Author : Erna Raja; Aristidis Moustakas; Tomi Mäkelä; Uppsala University Faculty of Medicine Ludwig Institute for Cancer Research; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell signalling; TGFbeta; BMP; LKB1; AMPK; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. READ MORE

  6. 19. The role of transforming growth factor‐β signaling and hypoxia‐inducible factors in renal cell carcinoma

    Author : Pramod Mallikarjuna; Maréne Landström; Börje Ljungberg; Raviprakash Tumkur Sitaram; Anders Bjartell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; Hypoxia; Renal cell carcinoma; ccRCC; non-ccRCC; transforming growth factor-β; ALK5; pVHL; HIF-α; SNAIL1; molekylärbiologi; Molecular Biology;

    Abstract : Renal cell carcinoma (RCC) is the cancer of the kidneys; about 1100 patients with RCC are diagnosed in Sweden each year. RCC can be classified into several subtypes, clear cell renal cell carcinoma (ccRCC) is most common accounting to about 70% of all RCCs, and also the most lethal; papillary renal cell carcinoma (pRCC) accounts to about 10%‐15%, while chromophobe renal cell carcinoma (chRCC) accounts to about 5% of all RCCs. READ MORE

  7. 20. Platelet-regulated CD4+ T effector cell responses in atherosclerosis

    Author : Shuai Tan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells are a key driving force of inflammation, plaque formation and instability. READ MORE