Search for dissertations about: "TGFβ"

Showing result 21 - 25 of 65 swedish dissertations containing the word TGFβ.

  2. 21. Proteome profiling of human breast cancer

    Author : Olena Zakharchenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer (BC) takes thousands of woman’s lives yearly. Several factors have been found to influence initiation and development of breast cancer, and to affect prognosis and treatment of this disease. READ MORE

  4. 22. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival

    Author : Maria Ekman; Marene Landström; Carl-Henrik Heldin; Jonas Fuxe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta; cell migration; invasion; apoptosis; Smad7; APC; ATM; TRAF6; p53; PC3U; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. READ MORE

  5. 23. Search for markers and molecular mechanisms of aggressive endometrial cancer : profiling of aggressive vs non-aggressive endometrial cancers

    Author : Sanaz Attarha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Endometrial cancer is the seventh frequent type of cancer among women. Identification of new prognostic markers is important to optimize treatment and follow-up of all EC patients. Understanding the molecular mechanisms of carcinogenesis may pave through discovery of further EC molecular markers. READ MORE

  6. 24. Pathways that govern hematopoietic stem cell fate

    Author : Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

    Abstract : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. READ MORE

  7. 25. Proteomics of invasiveness of human breast epithelial cells

    Author : Kah Wai Lin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mechanisms of malignant transformation and cancer invasion and factors controlling them in response to various stimuli remain elusive. We used proteomics and systems biology to explore these mechanisms in human breast epithelial cells. The objective has been to identify a set of biomarkers for diagnostics and prognostics of breast cancer. READ MORE