Search for dissertations about: "TGF-β signaling."

Showing result 1 - 5 of 39 swedish dissertations containing the words TGF-β signaling..

  1. 1. Diversification of TGF-β Signaling in Homeostasis and Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Michael Vanlandewijck; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; signaling; SIK; EMT; polarity; Notch; ALK5; p21; growth arrest; Smurf; Smad7; receptor; SNF1LK; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. READ MORE

  2. 2. Novel Regulators of the TGF-β Signaling Pathway

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marcin Kowanetz; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; Smad; Id; EMT; cell cycle; SNF1LK; ubiquitin; degradation; signal transduction; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. READ MORE

  3. 3. Regulation of TGF-β Signaling by Post-Translational Modifications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Peter Lönn; Uppsala universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. READ MORE

  4. 4. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Simonsson; Uppsala universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE

  5. 5. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α studies in two- and three dimensional in vitro models

    University dissertation from Örebro : Örebro university

    Author : Anita Koskela von Sydow; Örebro universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

    Abstract : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. READ MORE