Search for dissertations about: "TGN"
Showing result 1 - 5 of 8 swedish dissertations containing the word TGN.
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1. Development of new methodology for therapeutic drug monitoring of thiopurine treatment
Abstract : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). READ MORE
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2. Clinical studies of thiopurine metabolism in inflammatory bowel disease
Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE
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3. Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease
Abstract : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). READ MORE
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4. Understanding the Molecular Basis of Differential Growth during Apical Hook Development
Abstract : Plants’ adaptation to their environment often involves change in development, which in many cases involves the establishment of differential growth rates across organs, for instance during phototropic and gravitropic responses. A striking example of differential growth is the formation of the apical hook, a structure that forms to protect the apical meristem as seedlings penetrate through soil. READ MORE
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5. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
Abstract : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. READ MORE