Search for dissertations about: "TGf and stem cell"

Showing result 1 - 5 of 27 swedish dissertations containing the words TGf and stem cell.

2. 1. TGF-beta signaling in cancer

   Author : Erik Johansson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

   Abstract : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. READ MORE

4. 2. Regulation of cell polarity and invasion by TGF-β and BMP signaling

   Author : Mahsa Shahidi Dadras; Aristidis Moustakas; Petra Knaus; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; cancer stem cells; invasion; metastasis; polarity; TGF-β signaling.;

   Abstract : Transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling pathways are involved in many physiological processes during embryonic and adult life. TGF-β promotes epithelial to mesenchymal transition (EMT). We identified a gene target of TGF-β signaling, encoding the salt-inducible kinase 1 (SIK1). READ MORE

5. 3. Mast Cell Migration in Inflammatory Diseases

   Author : Niclas Olsson; Gunnar Nilsson; Jaroslaw Dastych; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Mast cells; chemotaxis; inflammation; Patologi; Pathology; Patologi;

   Abstract : Mast cells (MCs) are forceful multifunctional effector cells of the immune system. MCs are normally distributed throughout connective and mucosal tissues, but in several pathological conditions accumulation of MCs occur. READ MORE

6. 4. Regulation of cellular plasticity and extracellular vesicle secretion in breast cancer

   Author : Chrysoula Tsirigoti; Aristidis Moustakas; Carl-Henrik Heldin; Pierre Savagner; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular plasticity; extracellular vesicles; breast cancer; EMT; Molekylär medicin; Molecular Medicine; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : Epithelial-to-mesenchymal transition (EMT) is a dynamic process controlling the transition of cells between epithelial and mesenchymal states in various physiological or pathological conditions. In cancer, EMT promotes cell dissemination and metastatic colonization, enriches tumors with stem cell populations and confers resistance to anticancer therapy. READ MORE

7. 5. Smad signaling in hematopoietic stem cell biology

   Author : Göran Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smad7; Smad4; microarray; retroviral-mediated gene expression; conditional knockout; transforming growth factor beta; smad signaling; hematopoiesis; hematopoietic stem cells; Alk5; Medicine human and vertebrates ; Medicin människa och djur ;

   Abstract : Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. READ MORE