Search for dissertations about: "THDOC"
Found 4 swedish dissertations containing the word THDOC.
-
1. Progesterone metabolites : learning, tolerance, antagonism & metabolism
Abstract : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. READ MORE
-
2. Sex and stress steroid modulation of GABA mediated chloride ion flux in rat CNS
Abstract : Background: Sex and stress steroids are metabolized to 3a-hydroxy-pregnane-steroid metabolites such as allopregnanolone (Allo) and tetrahydrodeoxycorticosterone (THDOC). Allo and THDOC are neuroactive steroids that are metabolized in the brain and act in brain as potent positive GABAA receptor function modulators. READ MORE
-
3. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats
Abstract : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). READ MORE
-
4. Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte
Abstract : Introduction: Neuroactive steroids represent a class of both synthetic and naturally occurring steroids that have an effect on neural function. In addition to classical genomic mechanism by the hormones progesterone, deoxycorticosterone and testosterone 3α-OH metabolites of these hormones enhance GABAA receptor through rapid non-genomic mechanism. READ MORE