Search for dissertations about: "THE MOLECULAR MECHANISMS FOR MAINTENANCE OF"

Showing result 1 - 5 of 117 swedish dissertations containing the words THE MOLECULAR MECHANISMS FOR MAINTENANCE OF.

2. 1. The RNA exosome and the maintenance of genome integrity

   Author : Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

   Abstract : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. READ MORE

4. 2. The elephant in the cell : A multifaceted undertaking to uncover the molecular principles behind lymphatic endothelial cell identity

   Author : Virginia Panara; Katarzyna Koltowska; Taija Mäkinen; Marcel den Hoed; Sarah de Val; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lymphatic endothelium; Development; Epigenetic; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Abstract : The lymphatic vascular network is composed of a series of blind ended vessels, and is involved in physiological functions such as fluid homeostasis, lipid metabolism and immune trafficking. Despite lymphatic endothelial cells being derived from multiple organs, they share common molecular denominators, including the expression of the transcription factor Prox1. READ MORE

5. 3. Molecular ecology of marine mammals

   Author : Morten Tange Olsen; Per Palsbøll; Martine Bérubé; William “Bill” Amos; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Marine mammals; molecular ecology; life history; environmental change; phenotypic plasticity; SNPs; telomeres; molekylärgenetik; Molecular Genetics;

   Abstract : Marine mammals comprise a paraphyletic group of species whose current abundance and distribution has been greatly shaped by past environmental changes and anthropogenic impacts. This thesis describes molecular ecological approaches to answer questions regarding habitat requirements, genetic differentiation, and life-history trade-offs in three species of marine mammals. READ MORE

6. 4. Molecular and structural studies of proteins required for mitochondrial DNA maintenance

   Author : Carlos Pardo-Hernandez; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA; LONP1; POLγ; mtDNA maintenance; mitochondrial disease; TWINKLE; mitochondria;

   Abstract : Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), which codes for thirteen proteins needed for oxidative phosphorylation (OXPHOS). READ MORE

7. 5. Pericyte Influence on Drug Delivery Across the Blood-Brain Barrier : Implications for Therapy of Neurodegenerative Diseases

   Author : Nebojsa Mihajlica; Margareta Hammarlund-Udenaes; Christer Betsholtz; William Elmquist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; pericytes; pericyte-deficiency; pharmacokinetics; small-molecular drugs; drug distribution; transporters; P-glycoprotein; tyrosine kinase inhibitors; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. READ MORE