Search for dissertations about: "TIMP-1"

Showing result 6 - 10 of 45 swedish dissertations containing the word TIMP-1.

  2. 6. Colorectal cancer treatment and early response evaluation : how do we best evaluate treatment response?

    Author : Per Byström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Colorectal cancer; TIMP-1; tumor marker; PET; CEA; CA19-9; TPA; SAA; CRP; prealbumin; HRQoL;

    Abstract : Colorectal cancer (CRC) is common, being responsible for around 12% of new cancers in Sweden, and contributing heavily to the large numbers of cancer deaths yearly. CRC is the second most common cause of cancer death not only in Sweden but also worldwide. READ MORE

  4. 7. Genomic clues to secondary injury mechanisms in brain trauma

    Author : Christina von Gertten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : traumatic brain injury; cerebral cortical contusion; weight-drop model; depolarisation; gene expression; nestin; MMP-9; TIMP-1; osteopontin; CD44; hippocalcin; NMDA receptor; microarray; rat;

    Abstract : Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase TBI challenges clinical interventions due to its complexity. READ MORE

  5. 8. Proteolytic imbalance in COPD : epidemiological and clinical aspects

    Author : Robert Linder; Anders Blomberg; Anne Lindberg; Annelie F. Behndig; Arne Egesten; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Matrix metalloproteinases; MMP-9; MMP-12; lung function decline; epidemiology; COPD; OLIN; KOLIN; medicin; Medicine;

    Abstract : Background: The complete pathologic mechanism behind the development of chronic obstructive pulmonary disease (COPD) remains unclear, but several risk factors have been identified, of which smoking is the most common. Proteolytic imbalance contributes to lung tissue degradation and is related to both smoking and COPD symptoms. READ MORE

  6. 9. Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts

    Author : Helena Domeij; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Matrix metalloproteinases; tissue inhibitor of metalloproteinases; gingival fibroblasts; monocytes; periodontal diseases;

    Abstract : Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. READ MORE

  7. 10. Human ovulation. Studies on collagens, gelatinases and tissue inhibitors of metalloproteinases

    Author : Anna Karin Lind; Göteborgs universitet; []
    Keywords : ovulation; ovary; human; follicle; collagen; MMP and TIMP;

    Abstract : Ovulation is a highly regulated process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of a fertilizable oocyte. This unique biological process is initiated by the LH-surge, which induces major vascular changes and remodelling of the extracellular matrix (ECM) in and around the follicle. READ MORE