Search for dissertations about: "TMAs"

Showing result 1 - 5 of 6 swedish dissertations containing the word TMAs.

  1. 1. Image analysis of prostate cancer tissue biomarkers

    University dissertation from Division of Urological Cancers

    Author : Giuseppe Lippolis; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; image analysis; Time Resolved Fluorescence; automated Gleason; PSA; AR; fusion gene; TMAs;

    Abstract : Prostate cancer is the second most common cancer in men. In order to improve diagnosis and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. READ MORE

  2. 2. Tissue Microarrays for Analysis of Expression Patterns

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Lindskog Bergström; Fredrik Pontén; Anna Asplund; Ari Ristimäki; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue microarrays; Antibody-based proteomics; Immunohistochemistry; Biomarker discovery; Diabetes; Lung cancer; Influenza virus; Evolution; Pathology; Patologi;

    Abstract : Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). READ MORE

  3. 3. Protein Expression Profiling of Cancer Biomarkers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kristina Magnusson; Fredrik Pontén; Karin Jirström; Anna Dimberg; Tibor Tot; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody-based proteomics; Biomarker; SATB2; Colorectal cancer; ANLN; Breast cancer; CD93; Angiogenesis; Pathology; Patologi;

    Abstract : The Human Protein Atlas project is a Swedish research initiative that uses antibody-based proteomics for large scale protein profiling in human tissues and cells. Affinity-purified antibodies are produced within the project and used for immunohistochemical staining on tissue micro arrays (TMAs) in order to map the human proteome and publish the result in a protein atlas (www. READ MORE

  4. 4. Validation of antibodies for tissue based immunoassays

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sandra Andersson; Anna Asplund; Fredrik Pontén; Kenneth Wester; Mike Taussig; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibody validation; Conjugation; Estrogen receptor-beta; IHC; ISH; Lymphohematopoietic tissues; Proteomic; RNAseq; TMA; Transcriptomic; Patologi; Pathology;

    Abstract : In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. READ MORE

  5. 5. Immunohistochemical and molecular studies on ovarian cancer progression and prognosis

    University dissertation from Pathology, Lund University

    Author : Björn Nodin; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; prognostic and predictive biomarkers; tissue microarrays; androgen receptor; RBM3; Chek1; Chek2; MCM3; Dachshund 2; SATB1; KRAS mutation;

    Abstract : Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted therapeutics. READ MORE